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Weight loss and lean mass loss from burn induced catabolism can be more rapidly restored when the anabolic steroid oxandrolone is added to optimum nutrition compared to nutrition alone. The mechanism by which oxandrolone can effectively reverse the catabolic state induced by burnt fuel is due to its stimulating effects on catabolic enzymes and/or amino acid metabolism. It is believed that oxandrolone also stimulates mitochondrial fatty acid oxidation, which has been shown to increase mitochondrial biogenesis and increase antioxidant capacity through oxidation of the intracellular fatty acids (5). Oxandrolone, a selective and potent inhibitor of the catabolic enzymes glutathione reductase and protein S6K (5), has been found to activate the S6K/S6 kinase pathway at high doses that, over a short period of time, markedly decrease the expression of the antioxidant enzyme glutathione S-transferase and increase the content of superoxide anion (5,7). Oxandrolone is a selective inhibitor of protein catabolism (6), and is therefore efficacious in maintaining lipid-lipovitamins and protein levels at optimal levels. We have recently shown that oxandrolone can effectively reverse the effect of burnt fuel that occurs when oxandrolone is added to optimum nutrition as part of an oral supplement to patients with cardiovascular disease (7). Oxandrolone effectively reversed the catabolic state induced by ingested oxandrolone with a 5-day duration. For patients in whom oxandrolone does not completely reverse the anabolic state induced by oxandrolone (for example, in patients receiving an oral supplement that has not changed to a less-anabolic formulation), treatment of those patients should continue for 7 days. However, the patient should be monitored periodically for adverse events following treatment until the oxandrolone treatment is fully completed. The use of oxandrolone in patients with cardiovascular disease or patients with a high prevalence of cardiovascular disease should be discussed promptly with their physician prior to initiation of prescription of oxandrolone/iodophor combination for therapy of cardiovascular disease or patients with an elevated blood lipid level. For all patients, oxandrolone should only be used as directed by their physician during initiation of oxandrolone/iodophor combination therapy for cardiovascular disease or patients with a high prevalence of cardiovascular disease. Oxandrolone should be continued while oxandrolone plus oxandrolone should be stopped. Patients who undergo the administration procedure following prescription of oxandrolone/iodophor combination may receive oxandrolone/iodophor combination if they show no further adverse effects. Clinical Studies Similar articles:

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